Copyright
Aswin Sai Narain SeshasayeePublished On
2025-02-28Page Range
pp. 161–218Language
- English
Print Length
58 pages
5. Reading and organising the genome
The genome is informational rather than functional. This information must be read or “expressed”, eventually producing proteins or functional RNA molecules, for the cell to be active. This is a tightly regulated process orchestrated by a complex network of interactions between regulatory proteins and other molecules. Functional regions on a genome are usually non-randomly positioned, and this, while driven by how the genome is replicated during reproduction, also enables efficient gene expression.
Contributors
Aswin Sai Narain Seshasayee
(author)Aswin Sai Narain Seshasayee is a researcher and Associate Professor at the National Centre for Biological Sciences (NCBS), a centre of Tata Institute of Fundamental Research (TIFR) in Bangalore, India. His lab is interested in fundamental aspects of the function and evolution of bacterial genomes and gene regulatory networks. His career in the sciences started off with a Bachelors of Technology at Anna University, Chennai, India, during which a lot of time left alone to explore and break things in the bioinformatics laboratory of Professor Gautam Pennathur and in the experimental microbiology and protein engineering laboratory of Professor Sankaran encouraged him to take up research for a career. He then pursued research as an intern, a PhD student and then briefly a postdoc with Nicholas Luscombe at EMBL-European Bioinformatics Institute, Hinxton, Cambridge, UK (and St John’s College and Girton College, University of Cambridge). He has been with NCBS since December 2010, his research here funded over the years by the Department of Atomic Energy (Govt of India) core support to TIFR and NCBS, Department of Biotechnology, Department of Science and Technology and Science and Engineering Research Board (all Govt of India), CEFIPRA and DBT-Wellcome Trust India Alliance. Beyond science, he enjoys making music, painting watercolour landscapes and reading classic crime and fantasy fiction and popular history.